Table 4

Protective effect of ALDO and 11-OP on the inhibition of the steroid binding capacity of MR by pyridoxal 5′-phosphate

TreatmentBinding of [3H]ALDO
cpm/incubation
Control8180  ± 435
10 mM Pyridoxal 5′-phosphate + 60 mM l-Lys7295  ± 785
10 mM Pyridoxal 5′-phosphate1488  ± 381a
Preincubation with 20 nM ALDO5988  ± 880b 4-c
Preincubation with 300 nM 11-OP1377  ± 279a
Preincubation with 1 μM 6-OP1607  ± 556a
  • Different from control ataP < .001 andbP < .05.

  • 4-c Different from treatment of unoccupied MR atP < .001.