Table 1

A comparison of sensitivities of native T currents in DRG cells and α1G, α1H, and α1E currents in HEK cells

	Summary of Effects of Anesthetics and Anticonvulsants
	DRG^1-a	α1G^1-b	α1H^1-b	α1H	α1E^c
Propofol	IC₅₀ 12.9 μM; max. 100%	IC₅₀ 20 μM; max. 100%	IC₅₀ 27 μM; max. 100%
Octanol	IC₅₀ 122 μM; max. 100%	IC₅₀ 160 μM; max. 100%	IC₅₀ 218.6 μM; max. 100%		IC₅₀ 206 μM; max. 100%
Isoflurane	IC₅₀ 303 μM; max. 100%	IC₅₀ 271 μM; max. 100%
Pentobarbital	IC₅₀ 334 μM; max. 100%	IC₅₀ 310 μM; max. 100%	IC₅₀ 345 μM; max. 100%		IC₅₀ 600 μM; max. 100%
Phenobarbital	IC₅₀ 1.7 mM; max. 100%	IC₅₀1.54 mM; max. 100%			IC₅₀ 2.7 mM; max. 100%
ES	IC₅₀ 23.7 mM; max. 100%	IC₅₀ 14.3 mM; max. 100%	IC₅₀ 22.4 mM; max. 100%		IC₅₀ 20 mM; max. 100%
MPS	IC₅₀ 145 μM; max. 42%	IC₅₀ 1.67 mM; max. 100%	IC₅₀ 2.3 mM; max. ∼100%		IC₅₀ 2.3 mM; max. 100%
Phenytoin	IC₅₀ 7.8 μM; max. 58%	IC₅₀ 140 μM; max. 100%	IC₅₀ 8.3 μM; max. 44.8% (10 of 23 cells)	IC₅₀ 192 μM; max. 100% (13 of 23 cells)	IC₅₀ 360 μM; max. 100%

↵1-a Data for MPS and phenytoin from this study with 2 mM Ca²⁺, other data from Todorovic and Lingle (1998)with 10 mM Ba²⁺.
↵1-b This study with 2 mM Ca²⁺.
1-c From Nakashima et al. (1998) with 10 mM Ba²⁺.