Table 1

Effects of GABA and pentobarbital on single-channel parameters on burst duration

Burst Duration
0.5 μM GABA+100 μM PB100 μM PB
Time constant
 τ1 0.4  ± 0.30.5  ± 0.21.0  ± 0.6
 τ2 3.4  ± 0.8
 τ3 22  ± 422  ± 1019  ± 8
 τ4 87  ± 1973  ± 20
Area %
 A1 28  ± 98  ± 414  ± 4
 A2 36  ± 6
 A3 37  ± 1210  ± 544  ± 13
 A4 82  ± 742  ± 15

Time constants (τi, ms) and the relative areas (Ai) of burst duration for channels activated by 0.5 μM GABA alone and later 0.5 μM GABA plus 100 μM pentobarbital (n = 4) or activated by 100 μM pentobarbital alone (n = 6). Data were fitted with sums of three or four exponential functions (means ± 1 S.E.).

    • PB, pentobarbital.