Liver weight, ACO, and CYP4A in CD-1 mice
| Liver Weight ± S.E.M. | ACO ± S.E.M. | CYP4A ± S.E.M. | ||||
|---|---|---|---|---|---|---|
| Male | Female | Male | Female | Male | Female | |
| % body weight (% change) | nmol/min/mg (% change) | AU (% change) | ||||
| Vehicle | 6.19 ± 0.16 | 5.22 ± 0.14 | 3.16 ± 0.21 | 3.69 ± 0.29 | 0.33 ± 0.04 | 0.26 ± 0.04 |
| TZD, 500 mg/kg/day | 7.25 ± 0.26 (17)1-160 | 6.65 ± 0.11 (27)1-160 | 11.38 ± 2.98 (260)1-150 | 12.73 ± 2.86 (245)1-150 | 0.73 ± 0.05 (125)1-160 | 0.84 ± 0.05 (221)1-160 |
| Vehicle | 5.63 ± 0.11 | 5.20 ± 0.13 | 3.48 ± 0.42 | 4.63 ± 0.67 | 0.31 ± 0.05 | 0.19 ± 0.02 |
| L-783,483, 500 mg/kg/day | 7.65 ± 0.23 (36)1-160 | 8.27 ± 0.23 (59)1-160 | 24.63 ± 3.21 (720)1-160 | 25.95 ± 3.37 (460)1-150 | 0.94 ± 0.06 (206)1-160 | 1.06 ± 0.13 (466)1-150 |
Four CD-1 mice (each sex) were treated for 4 days as indicated; data for TZD represent two independent studies (eight animals per sex total). Values in parentheses represent percentage increase over concurrent vehicle control. CYP4A values have had an average preimmune background of 0.16 AU subtracted (previously determined).