Inhibitory effects of antiviral compounds against HIV-1 (NL4.3) strains selected for resistance against l-CA or d-CA
| EC50(μM)3-a (Fold Increase)3-b | |||
|---|---|---|---|
| NL4.3 WT | NL4.3l-CAres 3-c | NL4.3d-CAres 3-d | |
| l-CA | 12.7 ± 8.5 | 66.8 (5) | >115 (>9) |
| l-CATA | 8.0 ± 2.8 | 62.0 (8) | 37.0 (5) |
| d-CA | 10.9 ± 6.5 | >111 (>10) | >111 (>10) |
| d-CATA | 7.8 ± 2.6 | 75.7 (10) | 92.0 (12) |
| DS | 0.08 ± 0.08 | 2.1 (26) | 1.24 (16) |
WT, wild type.
↵3-a 50% effective concentration, or concentration required to inhibit the viral cytopathic effect by 50% in MT-4 cell cultures.
↵3-b Fold resistance is the ratio of EC50 determined for the resistant strain divided by the EC50 obtained for the HIV-1 NL4.3WT strain.
↵3-c Virus strain selected after 23 passages in MT-4 cells in the presence of increasing concentrations ofl-CA (up to 63.2 μM).
↵3-d Virus strain selected after 26 passages in MT-4 cells in the presence of increasing concentrations ofd-CA (up to 84.3 μM).
All data represent mean ± S.D. for at least two separate experiments.