Compound | IC50 (μM) | ||
---|---|---|---|
3′-Processing reaction | Strand transfer reaction | Overall reaction | |
l-CA | 1.0 ± 0.3 | >105 | 0.2 ± 0.2 |
l-CATA | 4.0 ± 2.1 | >78 | 0.6 ± 0.06 |
d-CA | 0.5 ± 0.1 | >105 | 0.3 ± 0.02 |
d-CATA | 4.5 ± 2.3 | >78 | 2.4 ± 0.08 |
DS | 0.07 ± 0.02 | 0.4 ± 0.1 | ND |
ND, not determined.
All data represent mean values ± S.D. for at least two independent experiments.