Table 6

Dissociation time constants of 5-substituted 9-aminoacridinecarboxamides

No.RTime ConstantsAmplitudesτ6-aτ−16-b
τ1τ2τ3τ4A1A2A3A4
ms % s s−1
1 H62886428143434180.128.6
 2 F6664801900135815150.402.5
 3 Cl8934102400124828120.452.2
 4 Br10913602200104631130.442.3
 5 CF3 126121013008582870.185.4
 6 NO2 967430160085625100.303.3
 7 SO2CH3 1378300110044131240.392.6
 8 NH2 21120500170017522380.323.2
 9 CH3 211103201400104330170.382.6
10 OCH3 1769300110042053230.432.3
11 OPr978310110082950130.323.1
12 Ph4113920053345170.05618
13 Ph-p-NO2 72584460103240170.128.3
14 6-c Ph-p-NH2 2310060046005926461.80.56
15 5,6-Benz364001600620083741141.70.60
  • Ph, phenyl; OPr, propoxy.

  • 6-a  τ, average dissociation time constant, s (τ = ΣrArτr).

  • 6-b  τ−1, average dissociation rate constant, s−1−1 = 1/τ).

  • 6-c  Fifth transient observed (τ5 = 29,000 ms; A5 = 5%).