Table 1

Kinetic values used for computer modelling of mecamylamine block of nicotine currents

	Model 1 (Fig. 8B)		Model 2 (Fig.8C)		Model 2 (Fig. 8D)		Model 2 (Fig. 8E)
	Values at 0 mV	H	Values at 0 mV	H	Values at 0 mV	H	Values at 0 mV	H
		mV		mV		mV		mV
k₁ ^⁺	40.8 μM⁻¹ s⁻¹		40.8 μM⁻¹s⁻¹		40.8 μM⁻¹s⁻¹		40.8 μM⁻¹s⁻¹
k₁ ⁻	4170 s⁻¹		4170 s⁻¹		4170 s⁻¹		4170 s⁻¹
k₂ ^⁺	20.4 μM⁻¹s⁻¹		20.4 μM⁻¹s⁻¹		20.4 μM⁻¹s⁻¹		20.4 μM⁻¹ s⁻¹
k₂ ⁻	8340 s⁻¹		8340 s⁻¹		8340 s⁻¹		8340 s⁻¹
β	460 s⁻¹		460 s⁻¹		460 s⁻¹		460 s⁻¹
α	45 s⁻¹	156	45 s⁻¹	156	45 s⁻¹	156	45 s⁻¹	156
k_b ^⁺	23 μM⁻¹ s⁻¹	−100	23 μM⁻¹s⁻¹	−100	23 μM⁻¹s⁻¹	−100	23 μM⁻¹s⁻¹	−100
k_b ⁻	42 s⁻¹	80	42 s⁻¹	80	42 s⁻¹	80	200 s⁻¹
α′			45 s⁻¹	156	45 s⁻¹	156	45 s⁻¹	156
β′			460 s⁻¹		220 s⁻¹		112 s⁻¹	22.5
k₂ ⁻′			8340 s⁻¹		8340 s⁻¹		8340 s⁻¹
k₂ ^⁺′			20.4 μM⁻¹ s⁻¹		20.4 μM⁻¹s⁻¹		20.4 μM⁻¹ s⁻¹
k₁ ⁻′			4170 s⁻¹		4170 s⁻¹		4170 s⁻¹
k₁ ^⁺′			40.8 μM⁻¹ s⁻¹		40.8 μM⁻¹s⁻¹		40.8 μM⁻¹s⁻¹