Table 3

Topoisomerase IIα allele polymorphism in DC-3F/S16

Nucleotide No.Nucleotide ChangeAmino Acid Change
Silent mutations in the BamHI-sensitive allele
 87T → CIle29 → Ile29
 342A → GLeu114 → Leu114
 2877T → CTyr959 → Tyr959
 3072C → TLeu1024 → Leu1024
 3630C → THis1210 → His1210
 3933C → TAsp1311 → Asp1311
 4314A → GSer1438 → Ser1438
 5114G → TNoncoding region
 5346A → GNoncoding region
 5408G → ANoncoding region
Missense mutation in DC-3F/S16
 1456A → GArg486 → Gly486

The accession number to the complete sequence of the DC-3F/S16 topoisomerase IIα cDNA in the EMBL/EBI database is Y16595.