CX614 | CTZ | |
---|---|---|
μM | ||
EPSP | ||
Amplitude | 30 | N.D.1-a |
Half-width | 18 | N.D.1-a |
Glutamate-induced currents, native receptors from CA1 pyramidal cells1-b | ||
Peak | 132 | |
Steady-state | 43 | |
% Steady-state/peak | 18 | 10 |
Glutamate-induced currents, recombinant homomeric receptors | ||
GluR1o | 21 | 74 |
GluR2o | 37 | |
GluR2i | 46 | 7 |
GluR3o | 19 | 78 |
GluR3i | 71 | 9 |
[3H]AMPA binding1-c | ||
GluR1o | 20 | 130 |
GluR2o | 18 | 49 |
GluR2i | 58 | 7 |
GluR3o | 40 | 73 |
GluR3i | 157 | 16 |
↵1-a No EC50 values were determined for cyclothiazide because it produced only minor changes in EPSP measures even after prolonged perfusion at 100 μM (Larson et al., 1994; Arai and Lynch, 1998b).
↵1-b CTZ data for patch currents are from Arai et al. (1996a).
↵1-c From Hennegriff et al. (1997) for binding data related to GluR1, GluR2, and GluR3 flop. Data for GluR3 flip were determined as in the study of Hennegriff et al. (1997)by measuring the drug effect on the binding of 10 nM [3H]AMPA in the presence of 50 mM potassium thiocyanate at 0°C.