Table 1

The CB1 cannabinoid receptor may induce JNK activation via transactivation of PDGF receptors

AdditionsJNK Activity
%
None100  ± 12
THC168  ± 171-150
PDGF196  ± 191-150
EGF93  ± 11
AG1296103  ± 4
AG1478109  ± 11
THC + AG1296112  ± 13
THC +AG1478181  ± 261-150
PDGF + AG1296110  ± 19

CHO-CB1 cells were incubated for 10 min with or without 30 μM tyrphostin AG1296 or 1 μM tyrphostin AG1478 and then with or without 1 μM THC, 1 nM PDGF, or 15 nM EGF for an additional 5 min. Results are expressed as percentage of incubations with no additions and correspond to four different experiments.

    • Significantly different from incubations with no additions:

    • ↵1-150  P < .01.