α-Subunits | [3H]Ro15-4513 (Kd) | Zopiclone (Ki) | Times Wild Type | Diazepam (Ki) | Times Wild Type |
---|---|---|---|---|---|
nM | nM | ||||
Wild type | 6.2 ± 0.542-a | 51.3 ± 5.4 | 19.4 ± 0.3 | ||
H101F | 0.95 ± 0.072-a | 199 ± 28 | 4 | 164 ± 49 | 8 |
H101Y | 7.01 ± 0.712-a | 863 ± 389 | 17 | 504 ± 51 | 25 |
H101Q | 0.49 ± 0.072-a | 761 ± 216 | 15 | 1476 ± 782 | 74 |
H101E | 2.13 ± 0.132-a | >10,000 | >10,000 | ||
H101K | 1.54 ± 0.112-a | >10,000 | >10,000 | ||
H101A | 8.3 ± 0.4 | >10,000 | >10,000 |
Values are means ± S.E. for at least three experiments performed in duplicate.
↵2-a Values reported previously (Davies et al., 1998).