Mean values of the EC50 of glycine and Hill coefficient for each type of GlyR
| GlyR Type | Gly EC50 (mean ± S.D.) | nH (mean ± S.D.) | Range of Maximum Responses | n |
|---|---|---|---|---|
| μm | μA | |||
| α1 | 150 ± 45 | 2.8 ± 0.5 | 42–107 | 6 |
| α1/β | 210 ± 15 | 3.07 ± 0.04 | 20–25 | 3 |
| α2 | 96 ± 28 | 3.2 ± 0.3 | 13–58 | 6 |
| α2/β | 157 ± 12 | 3.00 ± 0.37 | 31–74 | 3 |
A complete concentration-response curve was obtained from each oocyte and each curve was fitted by a Hill equation using kaleidagraph (see equation under Materials and Methods). Then, the EC50 and n H derived from these fits were averaged for oocytes expressing the same type of GlyR. The range of maximum responses is also indicated.