Table 2

Ratio of radioactivity (ng/g of tissue) and AUC [14C]CO2 in mdr1a (−/−),mdr1a/1b(−/−) mice compared to mdr1a(+/+) mice following [14C]N-methyl erythromycin injection

Mdr1a(+/+) (n = 4)Ratio mdr1a(−/−):(+/+) (n= 3)Ratio mdr1a/1b(−/−):(+/+) (n = 3)
4-h ERMBT
 Plasma radioactivity1  ± 0.661.50  ± 0.673.09  ± 0.65
 Liver radioactivity1  ± 0.171.41  ± 0.151.80  ± 0.14
 AUC0–240 1  ± 0.041.54  ± 0.071.91  ± 0.03
30-min ERMBT(n = 4)(n = 3)
 Liver radioactivity1  ± 0.191.44  ± 0.17
 AUC0–30 1  ± 0.091.59  ± 0.16

The values from the (+/+) mice were assigned the number 1.0.