Table 2

The K i of bromovinyl analogs for VZV TK and relative velocity to dThd

KiRelative Velocity to dThd2-a
μM
l-BVOddU125  ± 209.8  ± 2.7
d-BVOddU78  ± 301.56  ± 0.71
l-BVDU1.34  ± 0.47N.D.
d-BVDU0.09  ± 0.030.9  ± 0.09
dThd0.42-b 1.0

  • ↵2-a  In assay, the concentration of nucleosides used was 100 μM, and ATP-Mg was 2 mM. N.D., not determined.

  • ↵2-b  K m value of dThd for VZV TK is adopted from the paper by Cheng et al. (1979).