Mutant | −GABA4-a | +GABA4-a | +Diazepam |
---|---|---|---|
WT | — | — | — |
Y294C | ↓ | ↓ | ↓ |
F296C | — | ↓ | ↑ |
V297C | — | — | — |
F298C | — | ↑ | ↑ |
S299C | — | — | — |
A300C | — | ↑ | — |
L301C | — | ↑ | ↑ |
I302C | — | — | — |
E303C | — | ↓ | — |
—, no effect; ↑, potentiation of subsequent GABA-induced currents; ↓, inhibition of subsequent GABA-induced currents.
↵4-a Results in the presence and in the absence of GABA taken from Williams and Akabas (1999).