Table 2

Concentration-response parameters for A1 receptor agonist stimulation of cAMP accumulation (in the presence of 3 μM forskolin) after treatment of CHOA1H cells with PTX (24 h, 100 ng/ml)

AgonistLog EC50Maximum Response
M (-fold over basal)
CPA−7.16  ± 0.24 (6)2.09  ± 0.12 (6)
NECA−6.36  ± 0.15 (9)2.87  ± 0.32 (9)
R-PIA−7.21  ± 0.22 (7)1.96  ± 0.13 (7)

Values represent means ± S.E.M. from the number of experiments given in parentheses.