[3H]Idazoxan-specific binding in wild-type and MAO-deficient mice
| Wild-Type MAO A | MAO A KO | Wild-Type MAO B | MAO B KO | ||||
|---|---|---|---|---|---|---|---|
| Bmax | Kd | Bmax | Kd | Bmax | Kd | ||
| fmol/mg protein | nM | fmol/mg protein | nM | fmol/mg protein | nM | ||
| Liver | 364 ± 12.5 | 6.1 ± 0.9 | 375 ± 16 | 3.5 ± 1 | 455 ± 16.5 | 8.7 ± 0.9 | N.D. |
| Brain | 62 ± 6.5 | 11.5 ± 2.5 | 41 ± 6.5 | 6.4 ± 2.2 | 68 ± 5.5 | 9.4 ± 2.1 | N.D. |
Values represent the means ± S.E.M. of three independent experiments.
N.D., not detectable.