Antiretroviral activity of dendrimers BRI2923 and BRI6195 and DS
| Virus | Strain | Cells | EC501-a(μg/ml) | ||
|---|---|---|---|---|---|
| BRI2923 | BRI6195 | DS | |||
| HIV-1 | IIIB | MT-4 | 0.3 ± 0.2 | 0.1 ± 0.06 | 0.4 ± 0.3 |
| C8166 | 0.3 ± 0.01 | 0.1 ± 0.04 | 0.2 ± 0.2 | ||
| PBMC | 2.2 ± 1.5 | 9.1 ± 4.2 | 0.4 ± 0.2 | ||
| NL4.3 | MT-4 | 0.4 ± 0.3 | 0.4 ± 0.2 | 0.4 ± 0.4 | |
| RF | MT-4 | 0.1 ± 0.02 | 0.1 ± 0.02 | 0.8 ± 0.3 | |
| HE | MT-4 | 1.0 ± 0.4 | 3.5 ± 2.8 | 2.1 ± 0.5 | |
| L1 | MT-4 | 0.9 ± 0.9 | 0.5 ± 0.1 | 3.3 ± 4.0 | |
| HIV-2 | ROD | MT-4 | 0.7 ± 0.5 | 1.7 ± 0.6 | 0.04 ± 0.03 |
| EHO | MT-4 | 0.01 ± 0.008 | 2.1 ± 0.7 | 10.6 ± 4.8 | |
| SIV | MAC251 | MT-4 | 0.8 ± 0.2 | 1.2 ± 0.6 | 3.5 ± 1.9 |
↵1-a Concentrations of each compound required to inhibit the CPE of retroviruses in cell culture by 50%.