Cytotoxicity of oxaliplatin and cisplatin
| Cell Line | Treatment | GI50 | |
|---|---|---|---|
| Cisplatin | Oxaliplatin | ||
| μM | |||
| CEM | Continuous1-a | 1.11 ± 0.05 | 1.19 ± 0.17 |
| CEM | Pulse 1 h1-b | 11.37 ± 1.48 | 11.38 ± 1.12 |
| A2780 | Continuous1-c | 0.38 ± 0.16 | 0.21 ± 0.04 |
| A2780PR | Continuous1-c | 3.82 ± 0.31 | 2.22 ± 0.74 |
| HCT116 | Continuous1-c | 11.73 ± 0.30 | 1.79 ± 0.19 |
| HT29 | Continuous1-c | 8.27 ± 1.90 | 1.28 ± 0.29 |
↵1-a Determined based on cell counts after a continuous incubation for 48 h (approximately 3 × cell generation time) with drug concentrations ranging from 0.01 to 100 μM.
↵1-b Determined based on cell counts after a 1-h pulse treatment with drug concentrations ranging from 0.1 to 100 μM, followed by a 48-h postincubation in drug-free medium.
↵1-c Determined by the MTT assay after a 72-h incubation (approximately 3 × cell generation times) with drug concentrations ranging from 0.075 to 200 μM.