Parameters for the ternary complex models
| Symbol | Definition |
|---|---|
| [Ri] | Concentration of receptor in the inactive state (i.e., this species does not activate G proteins). |
| [G] | Concentration of G protein in the system. |
| K A | Equilibrium dissociation constant of the agonist-receptor complex. |
| K G | Equilibrium dissociation constant of the receptor-G protein complex. |
| γ | Factor defining the differential affinity of the receptor for G proteins when the receptor is ligand-bound. |
| L | Allosteric constant denoting the ratio of receptor in the active vs. inactive state (L = [Ra]/[Ri]). |
| α | Factor defining the differential affinity of an agonist for the active vs. the inactive state. |
| β | Factor defining the differential affinity of the receptor for G protein when the receptor is in the active state. |
| δ | Factor defining the synergy produced by simultaneous ligand binding and receptor activation on the interaction of the G protein with receptor. |