Table 1

Comparison of affinity for the [³H]CP-526,427 binding site and potency for inhibition of a functional AMPA receptor mediated response. IC₅₀ values were determined for inhibition of binding of 3 nM [³H]CP-526,427 binding to rat forebrain membranes (Binding IC₅₀) and for inhibition of ⁴⁵Ca²⁺uptake in primary cultures of rat cerebellar granule neurons induced by 100 μM kainate (Functional IC₅₀) as described underMaterials and Methods.