Antileukemic activity (murine P388 system) of mixed E and mixed Z complexes1-a
| Complex | Dose | %T/C1-b | Body Weight Variation1-c |
|---|---|---|---|
| mg/kg, qd1–7 | % | ||
| Vehicle | +5.5 | ||
| MixedE | 5 | 121 | 0 |
| 10 | 128 | −1.8 | |
| 15 | 152 | −3.1 | |
| 20 | 1321-d | −6.2 | |
| Mixed Z | 5 | 140 | −1.5 |
| 10 | 165 | −2.4 | |
| 15 | 1731-e | −5 | |
| 20 | 1901-f | −5 |
↵1-a P388 leukemia cells (106/mouse) were implanted i.p. on day 0 in B6D2F1 female mice (18 g of body weight, six animals/group, eight controls. The treatment with platinum complexes freshly dissolved in saline was performed i.p. on days 1 to 7 (qd1–7).
↵1-b %T/C, mean survival time (%) of treated animals vs. controls.
↵1-c Body weight variation at the end of treatment with respect to day 0.
↵1-d Two of six toxic deaths.
↵1-e One of six cures.
↵1-f Two of six cures.