Table 1
Comparison of the affinities of various PGF2α analogs for PGT and the FP receptor
| Compound Structure | AGN Number | pKa | IC50(nM) PG Transporter | IC50 (nM) FP Receptor |
|---|---|---|---|---|
| Prostaglandin F2α | 4.5 | 45 | 48 | |
| AGN 191365 | 4.5 | 307 | >710,000 | |
| AGN 191366 | 4.5 | 71 | 8,128 | |
| AGN 190910 | Neutral | Not determined | >10,000 | |
| AGN 190911 | Neutral | 7,300 | >10,000 | |
| AGN 194394 | 2.0 | 34 | >10,000 | |
| AGN 191995 | 4.5 | 330,000 | 228 | |
| AGN 192151 | Neutral | 630,000 | >10,000 | |
| AGN 191088 | 10.0 | 710,000 | >10,000 | |
| 17-Phenyl PGF2α | 4.5 | 168 | 18 | |
| Prostaglandin F2α 1-isopropyl ester | Neutral | >5,000 | 3,200 |