Table 5

Electrostatic contribution to the thermodynamic binding properties of the test compounds to ctDNA in ETN buffer, pH 7.0, 25°C

Compoundm′5-a−ΔG05-b−ΔG5-c
kJ/mol
BBR 35762.60  ± 0.1225.3  ± 1.034.6  ± 1.0
BBR 34382.49  ± 0.1325.7  ± 0.934.8  ± 1.1
MX1.95  ± 0.1230.7  ± 1.133.8  ± 0.9

  • ↵5-a  Number of ionic interactions per bound drug.

  • ↵5-b  Nonelectrostatic free energy contribution to the binding process.

  • ↵5-c  Free energy of binding at physiological (0.15 M) NaCl concentration.