Table 1

Cytostatic activity of antiherpetic nucleoside analogs against HSV-1 TK(WT) gene- and HSV-1 TK(Q125N) gene-transfected Ost TK−cells

CompoundIC50IC50ratio1-b
Ost TK−/HSV-1 TK(WT)+1-aOst TK−/HSV-1 TK(Q125N)+
μm
BVDU0.035  ± 0.0060.015  ± 0.0070.4
BVaraU0.004  ± 0.00150  ± 3512,500
S-BVDU0.008  ± 0.0040.024  ± 0.0063.0
araT0.004  ± 0.0010.53  ± 0.11133
GCV0.0011  ± 0.00050.0006  ± 0.00030.5
LBV0.008  ± 0.0010.006  ± 0.0030.8
ACV0.059  ± 0.0150.079  ± 0.0191.3
PCV0.013  ± 0.0020.020  ± 0.0021.5
BCV0.006  ± 0.0000.005  ± 0.0010.8

Data are the mean ± S.D. of at least three independent experiments.

    • ↵1-a  Data taken from Degreve et al. (1999).

    • ↵1-b  Ratios of IC50 values for Ost TK−/HSV-1 TK(Q125N)+ cells versus the IC50values for Ost TK−/HSV-1 TK(WT)+ cells.