MGBG concentration of control RW-4 and mutated SPMKO cells grown in the presence of 10 μM MGBG for time periods indicated. The values are means ± S.E.M. of triplicate cultures.
| Cell line | MGBG concentration | ||
|---|---|---|---|
| 2 h | 6 h | 12 h | |
| pmol/106cells | |||
| RW-4 | n.d. | 104.0 ± 28.5 | 309.7 ± 35.9 |
| SPMKO | 147.0 ± 8.9 | 729.7 ± 83.74-165 | 1087 ± 14.54-165 |
n.d., not detectable.
↵4-165 p < 0.001 statistical significance between drug-exposed parental and targeted cells.