DENSPM concentration of control RW-4 and mutated SPMKO cells grown in the presence of 50 μM DENSPM for time periods indicated. The values are means ± S.E.M. of triplicate cultures
| Cell line | DENSPM concentration | ||
|---|---|---|---|
| 6 h | 24 h | 48 h | |
| pmol/106 cells | |||
| RW-4 | 977.3 ± 29.7 | 2395.7 ± 45.5 | 2069.7 ± 143.6 |
| SPMKO | 2157.0 ± 169.36-165 | 2457.7 ± 367.6 | 1591.0 ± 14.2 |
n.d., not detectable.
↵6-165 p < 0.001 statistical significance between drug-exposed parental and targeted cells.