Pharmacological profiles of NPY and J-115814 for mouse NPY receptors
| Binding affinity (Ki) | [Ca2+]i Responses | |||||||
|---|---|---|---|---|---|---|---|---|
| hY1 | rY1 | mY1 | hY2 | hY4 | hY5 | mY6 | hY1 | |
| nM | ||||||||
| (EC50;nM) | ||||||||
| NPY | 0.47 ± 0.04 | 0.98 ± 0.16 | 0.96 ± 0.21 | 0.10 ± 0.02 | 130 ± 37 | 1.2 ± 0.33 | 3.7 ± 0.88 | 0.76 ± 0.33 |
| (IC50;nM) | ||||||||
| J-115814 | 1.4 ± 0.16 | 1.8 ± 0.18 | 1.9 ± 0.22 | >10000 | 620 ± 50 | 6000 ± 460 | >10000 | 6.8 ± 2.1 |
Y1, Y2, Y5, and Y6 affinities determined using 125I-PYY, Y4 affinity determined using 125I-PP. Data represent the mean of more than three independent determinations performed in duplicate.