Table 1
Effects of quinazolone-alkylcarboxylic acid derivatives (0.01 mM) on the fast- and slow-phase Ca2+ ion permeability responses of AMPA receptors in suspensions of resealed plasmalemmal fragments and nerve endings from the rat cerebral cortex at 30°C
| Additives | Functional Response | ||||
|---|---|---|---|---|---|
| Fast-Phase | Slow-Phase | ||||
| JA/α | JA/α (%) | JB/β | JB/β (%) | ||
| (S)-AMPA | None | 0.5 | 100 | 2.7 | 100 |
| (S)-AMPA | Q1—R: | 0.5 | 100 | 0.5 | 20 |
| —CH2COOH | |||||
| (S)-AMPA | Q2—R: | 0.5 | 100 | 7.3 | 270 |
| —(CH2)2COOH | |||||
| (S)-AMPA | Q3—R: | 0.5 | 100 | 5.7 | 210 |
| —CH2COOCH3 | |||||
| (S)-AMPA | Q4—R: | 0.5 | 100 | 2.7 | 100 |
| —CH2CON(C2H5)2 | |||||
| (S)-AMPA |
| 0.0 | 0 | 1.1 | 40 |
| (S)-AMPA | 0.5 | 100 | 3.3 | 120 | |
Values were rounded to the closest decimal number.