mAChR antagonist binding in HA and HV membrane homogenate
| Ligand | HA | HV | ||
|---|---|---|---|---|
| pKiH | pKiL | pKiH | pKiL | |
| nM | nM | |||
| Pirenzepine | 8.4 ± 0.7 | 6.3 ± 0.1 | 8.6 ± 1.2 | 6.1 ± 0.8 |
| (28.7 ± 8.7%) | (30.3 ± 10.4%) | |||
| Methoctramine | 8.6 ± 0.3 | 6.9 ± 0.3 | 8.8 ± 0.7 | 6.7 ± 0.5 |
| (77.5 ± 6.6%) | (78.2 ± 9.8%) | |||
| 4-DAMP | 9.2 ± 0.2 | 7.9 ± 0.2 | 9.1 ± 0.4 | 7.7 ± 0.3 |
| (22.1 ± 4.2%) | (15.4 ± 2.5%) | |||
| Tropicamide | 7.4 ± 0.4 | 6.2 ± 0.2 | 7.3 ± 0.8 | 6.2 ± 0.8 |
| (20.5 ± 5.5%) | (18.7 ± 8.4%) | |||
K iH and K iL represent high- and low-affinity dissociation constants; values in the parentheses indicate the percentage of high-affinity binding.