Agonists | Ki | KiH | KiL | % H of All Sites |
---|---|---|---|---|
nM | nM | nM | ||
(R)-Epinephrine | 361 ± 38 | 27.5 ± 4.6 | 659 ± 125 | 20 ± 9 |
(R)-Norepinephrine | 1,650 ± 330 | 0.44 ± 0.06 | 4,400 ± 420 | 30 ± 5 |
(S)-Norepinephrine | 7,130 ± 80 | 1,000 ± 430 | 17,200 ± 500 | 31 ± 2 |
UK-14,304 | 13.0 ± 0.57 | 0.68 ± 0.02 | 36.9 ± 1.00 | 41 ± 2 |
p-Aminoclonidine | 20.7 ± 0.66 | 5.5 ± 0.23 | 118 ± 32 | 55 ± 6 |
Two-site models were statistically significantly superior (p < 0.05), compared with one-site fits for the agonists listed in this table but not for the other agonists included in Table 2.
H, high-affinity agonist binding sites; L, low-affinity agonist binding sites.