Table 1

Kinetic parameters of the interaction between ribosomal complex C and the macrolides tylosin, erythromycin and azithromycin

ParameterTylosinErythromycinAzithromycin
K i (nM)2950  ± 100
K i * (nM)4.98  ± 0.30
k 4 (min−1)1.36  ± 0.20
k 5 (min−1 × 10−3)2.30  ± 0.30
K er (nM)393  ± 22
K er * (nM)36  ± 3
K az (nM)48  ± 5
K az * (nM)7.1  ± 0.4
k 6 (min−1)0.59  ± 0.090.086  ± 0.011
k 7(min−1)0.060  ± 0.0080.015  ± 0.001
k 4/K i (M−1s−1 × 104)0.77  ± 0.11
k 6/K er (M−1s−1 × 104)2.5  ± 0.2
k 6/K az (M−1s−1 × 104)3.0  ± 0.3