Table 2
The effects of modifications at the C-15 position on potency
| Compound | Trivial name | EC50 cmpd/EC50PGE2 |
|---|---|---|
| 8 | PGE2 | 1 |
| 12 | 15(S) -15-Methyl-PGE2 | 2.4 |
| 28 | 15-keto-PGE2 | 93 |
| 40 | 15(R) -15-Methyl-PGE2 | 540 |
| 42 | 15(R) -PGE2 | 870 |
| 14 | PGE1 | 1 (3.2) |
| 38 | 15(R) -PGE1 | 140 (460) |
| 15 | PGF2α | 1 (10) |
| 21 | 15(S) -15-Methyl-PGF2α | 2.7 (27) |
| 52 | 15(R) -PGF2α | >400 (>4000) |
| 36 | Misoprostol free acid | 330 |
Results are reported as fold reduction in potency relative to the root structure in each group with parenthetical values relative to PGE2. For compounds in which no root structure was available (bold), results are reported relative to PGE2. Compounds are numbered according to Table1.
