Table 3
The effects of modifications to the carboxylic acid moiety on potency
| Compound | Trivial name | EC50 cmpd/EC50 PGE2 |
|---|---|---|
| 8 | PGE2 | 1 |
| 34 | PGE2 methyl ester | 250 |
| 44 | PGE2ethanolamide | 1000 |
| 14 | PGE1 | 1 (3.2) |
| 47 | PGE1 methyl ester | 420 (1300) |
| 15 | PGF2α | 1 (10) |
| 50 | PGE2αmethyl ester | >240 (>2400) |
| 23 | Latanoprost free acid | 1 (41) |
| 51 | Latanoprost isopropyl ester | >63 (>2600) |
| 36 | Misoprostol free acid | 1 (330) |
| 55 | Misoprostol methyl ester | >300 (>10,000) |
| 13 | Sulprostone | 3.0 |
| 18 | Enprostil | 13 |
Results are reported as fold reduction in potency relative to the root structure in each group with parenthetical values relative to PGE2. For compounds where no root structure was available (bold), results are reported relative to PGE2. Compounds are numbered according to Table 1.
