Table 8
The effects of saturation at the 13,14 double bond on potency
| Compound | Trivial name | EC50cmpd/EC50 PGE2 |
|---|---|---|
| 28 | 15-keto-PGE2 | 1 (93) |
| 33 | 13,14-dihydro-15-keto-PGE2 | 2.7 (250) |
| 14 | PGE1 | 1 (3.2) |
| 11 | 13,14-dihydro-PGE1(PGE0) | 0.728-150 (2.3) |
| 15 | PGF2α | 1 (10) |
| 37 | 13,14-dihydro-PGF2α | 34 (340) |
| 7 | 17-phenyl-ω-trinor-PGF2α | 1 (0.92) |
| 23 | Latanoprost free acid | 45 (41) |
Results are reported as fold reduction in potency relative to the root structure in each group with parenthetical values relative to PGE2. Compounds are numbered according to Table 1.
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↵8-150 , not significantly different from the root structure.