cAMP, PLC, and PLD responses to VIP in CHO cells expressing VPAC1 and VPAC2 receptors
| VPAC1 | VPAC2 | |||
|---|---|---|---|---|
| EC50 | Emax | EC50 | Emax | |
| nM | fold of basal | nM | fold of basal | |
| cAMP Production | 0.065 ± 0.013 | 59 ± 1 | 0.123 ± 0.016 | 118 ± 3 |
| [3H]InsP production | nil at 3 μM | nil at 3 μM | ||
| [3H]PtdBut production | 6.2 ± 2.5 | 1.83 ± 0.29 | 5.3 ± 1.2 | 2.79 ± 0.46 |