Table 4

cAMP, PLC, and PLD responses to PACAP-38 in CHO cells expressing PAC1-null and PAC1-hop1 receptors

PAC1-nullPAC1-hop1
EC50EmaxEC50Emax
nM fold of basal nM fold of basal
cAMP Production0.027  ± 0.002169  ± 40.022  ± 0.002157  ± 18
[3H]InsP production4.7  ± 0.615.9  ± 0.38.9  ± 0.46.9  ± 0.1
[3H]PtdBut production1.7  ± 0.53.8  ± 0.23.0  ± 0.28.4  ± 0.1