Quinacrine | τd | |
---|---|---|
α2βɛδ | α2βγδ | |
μM | ms | |
0 | 44.0 ± 17 (56) | 41.1 ± 10.9 (31) |
1 | 9.7 ± 2.7 (7) | 12.2 ± 1.8 (5) |
3 | 4.5 ± 0.8 (13) | 6.0 ± 0.6 (3) |
6 | 2.7 ± 0.3 (11) | 3.7 ± 0.8 (5) |
10 | 1.8 ± 0.3 (7) | 2.8 ± 0.5 (3) |
30 | 0.9 ± 0.1 (3) |
The table shows the decay time constants (τd) of currents obtained from outside-out patches exposed to 300 μM ACh containing adult (α2βɛδ) and embryonic (α2βγδ) nAChRs. Values are expressed as the mean ± S.D. Number of experiments for each condition are shown in parentheses. Membrane potential, −50 mV.