Effects of quinacrine on equilibrium binding of ACh
| Condition | Kd | nH | N |
|---|---|---|---|
| μM | |||
| Control | 1.90 ± 0.5 | 1.18 ± 0.20 | 7 |
| 10 μM Quinacrine | 1.78 ± 0.5 | 1.10 ± 0.13 | 4 |
| 60 μM Quinacrine | 1.35 ± 0.4 | 1.00 ± 0.21 | 6 |
| 60 μM Proadifen | 0.14 ± 0.06 | 0.82 ± 0.13 | 8 |
| 60 μM Proadifen + 10 μM quinacrine | 0.15 ± 0.06 | 1.00 ± 0.10 | 2 |
The apparent affinity constant (K d) and Hill coefficient (n H) for ACh binding under the specified condition. N corresponds to the number of experiments.