Fit Parameter | BC3H1 | WT | 10′αβ | 6′αδ |
---|---|---|---|---|
EC50 (μM) | 20 | 14.5 ± 3.0 | 8.4 ± 1.8 | 5.7 ± 1.3 |
nH | 1.6 | 1.8 ± 0.4 | 2.0 ± 0.4 | 1.9 ± 0.8 |
Concentration-response data (Fig. 3) were fit to the Hill equation (seeResults). Results are presented as best fit parameter ±90% confidence limit. Data for receptors in BC3H1 cells are fromDilger and Brett, 1990, and consider a wider concentration range (0.3–1000 μM) than the other experiments.