Parameters used in the fitting of the inhibition data in Fig. 5
| Property | BC3H1 | WT | 10′αβ | 6′αδ |
|---|---|---|---|---|
| Ki (mM) | 0.9 ± 0.1 | 1.4 ± 0.1 | 0.30 ± 0.02 | 1.2 ± 0.1 |
| n | 1.7 ± 0.2 | 1.45 ± 0.14 | 1.50 ± 0.14 | 1.52 ± 0.09 |
| K1 (mM) | 3.9 ± 1.8 | 3.0 ± 0.8 | 0.59 ± 0.19 | 2.6 ± 0.5 |
| K2(mM) | 0.36 ± 0.27 | 1.2 ± 0.7 | 0.36 ± 0.21 | 1.1 ± 0.4 |
Ki and n are used in the Hill Equation fit (eq. 1); K1 and K2 are used in the two-site model fit (eq. 2).