Competition parameters of several compounds for (±)-[3H]DOB-labeled receptors in CHOFA4 cells expressing human 5-HT2A receptors
| −LogIC50high | −LogIC50low | %High | nH3-a | |
|---|---|---|---|---|
| MDL 100,907 | 9.28 ± 0.15 | 6.51 ± 0.24 | 59.5 ± 3.9 | 0.32 ± 0.01 |
| MDL 100,907 plus 100μM Gpp(NH)p | 9.87 ± 0.16 | 6.03 ± 0.22 | 56.2 ± 3.9 | 0.29 ± 0.01 |
| Ketanserin | 8.03 ± 0.38 | 5.04 ± 0.18 | 24.6 ± 4.7 | 0.44 ± 0.02 |
| Ketanserin plus 100μM Gpp(NH)p | 7.66 ± 0.39 | 4.70 ± 0.27 | 30.3 ± 5.9 | 0.38 ± 0.01 |
| SB242084 | 5.22 ± 0.11 | 1.00 | ||
| SB242084 plus 100μM Gpp(NH)p | 5.11 ± 0.09 | 1.00 | ||
| Mesulergine | 6.91 ± 0.12 | 1.00 | ||
| Mesulergine plus 100μM Gpp(NH)p | 6.57 ± 0.13 | 1.00 | ||
| 5-HT | 6.92 ± 0.18 | 1.00 | ||
| 5-HT plus 100μM Gpp(NH)p | 7.09 ± 0.19 | 1.00 |
Values represent mean ± S.E.M. of at least three independent experiments performed with duplicate points.
↵3-a Hill coefficient.