Table 1
Effect of GTX I on wild-type and chimeric sodium channels
| Wild-Type/Chimera | Amino Acid Sequence | Relative Chord Conductance [mean ± S.D. (number of observations)] |
|---|---|---|
| Wild-type μ1 | 0.35 ± 0.04 (n = 9) | |
| Wild-type rH1 | 0.22 ± 0.05 (n = 8)1-150 | |
| SHHH | 0.52 ± 0.08 (n = 6)1-150 | |
| HSSS | 0.16 ± 0.04 (n = 6)1-150 | |
| HHHS | 0.13 ± 0.04 (n = 3)1-150 | |
| SSSH | Not Expressed | |
| μ1 chim 1 | 0.23 ± 0.02 (n = 9)1-150 | |
| rH1 chim 1 | 0.34 ± 0.06 (n = 7) |
-
↵1-150 p < 0.01 vs. wild-type μ1 (Student's t test).