Table 1

The pK _i and pEC₅₀ values of the tested agonists for the human H₁ receptor and their intrinsic activities (α)

Compound	pK_i	n	[³H]InsP₃Assay		NF-κB Reporter-Gene Assay
Compound	pK_i	n	pEC₅₀	α	n	pEC₅₀	α	n
Histamine	4.2 ± 0.1	3	7.4 ± 0.1	1.00	18	6.8 ± 0.1	1.00	37
2-(3-Fluoromethylphenyl)histamine	5.2 ± 0.1	3	6.3 ± 0.1	0.93 ± 0.03	3	6.0 ± 0.1	0.96 ± 0.07	3

The values are expressed as means ± S.E.M. of separate experiments, each performed in triplicate.