IC50 values (96-h) for sensitive and resistant cell lines
| Drug | HCT116 | HCT116/8FP | Resistance Factor |
|---|---|---|---|
| Roscovitine | 5.67 ± 0.64 | 7.85 ± 2.95 | 1.00 ± 0.16 |
| Purvalanol A | 3.18 ± 0.38 | 2.48 ± 0.19 | 0.78 ± 0.07 |
| 9-Nitropaullone | 0.22 ± 0.03 | 0.21 ± 0.01 | 0.99 ± 0.14 |
| Hymenialdisine | 3.40 ± 0.85 | 2.63 ± 0.38 | 0.82 ± 0.30 |
| Etoposide | 0.41 ± 0.15 | 0.44 ± 0.17 | 1.19 ± 0.54 |
| Doxorubicin | 0.34 ± 0.37 | 0.19 ± 0.08 | 1.28 ± 0.92 |
| Cisplatin | 2.78 ± 1.40 | 4.35 ± 1.70 | 1.42 ± 0.22 |
| Raltitrexed | 0.01 ± 0.00 | 0.01 ± 0.00 | 1.00 ± 0.00 |
| Paclitaxel | 3.90 ± 3.50 | 5.90 ± 1.90 | 2.30 ± 1.5 |
| Topotecan | 7.40 ± 1.64 | 12.33 ± 1.90 | 1.7 ± 0.61 |
Data are shown in micromolar (except paclitaxel and topotecan, which are in nanomolar) as mean ± S.D. (n ≥ 3). Resistance factor is calculated as IC50 of HCT116/8FP/IC50 of HCT116 for each individual experiment and is shown as mean ± S.D.