Table 2
Structure-activity relationship of LPA receptor ligands
| Compound | R1 | R2 | R3 | X | R4 |
|---|---|---|---|---|---|
| LPA 18:1 | H | H | OH | CH2 | OCO(C17H33) |
| PA (8:0) | H | H | OCO(C7H15) | CH2 | OCO(C7H15) |
| DGPP (8:0) | OPO3 | H | OCO(C7H15) | CH2 | OCO(C7H15) |
| NAEPA | H | H | H | NH | CO(C17H33) |
| NP-ser-PA | H | COOH | H | NH | CO(C15H31) |
| VPC12204 | H | Benzyl-4-oxybenzyl | H | NH | CO(C17H33) |
| VPC12249 | H | H | Benzyl-4-oxybenzyl | NH | CO(C17H33) |