Effects of CGP7930 on the binding of [3H]APPA to native GABAB receptors in rat cortical membranes
| CGP7930 | KD | Bmax | n |
|---|---|---|---|
| μM | nM | fmol/mg of protein | |
| 0 (control) | 23.4 ± 0.5 | 581 ± 23 | 3 |
| 30 | 8.5 ± 1.63-150 | 624 ± 46 | 3 |
The binding of [3H]APPA ([3H]CGP27492) to rat cortical membranes was measured in the absence and in the presence of CGP7930 as described under Materials and Methods. The data shown are means ± S.E.M. from three independent experiments.
↵3-150 , significantly different from the control value (p < 0.01, t test).