Mouse | Genotype | DEB | 4-OH-DEB | Total | MR |
---|---|---|---|---|---|
1 | fl/fl,CRE−/−,2D6+/− | 22.8 | 8.8 | 31.7 | 2.6 |
2 | fl/fl,CRE−/−,2D6+/− | 19.6 | 7.2 | 26.8 | 2.7 |
3 | fl/fl,CRE−/−,2D6+/− | 16.0 | 7.2 | 23.2 | 2.2 |
4 | fl/fl,CRE−/−,2D6+/− | 14.8 | 5.5 | 20.3 | 2.7 |
MEAN | 18.3 | 7.2 | 25.5 | 2.6 | |
S.D. | 3.7 | 1.4 | 4.9 | 0.2 | |
1 | fl/fl,CRE+/−,2D6+/− | 10.4 | 2.8 | 13.2 | 3.7 |
2 | fl/fl,CRE+/−,2D6+/− | 9.7 | 2.5 | 12.3 | 3.8 |
3 | fl/fl,CRE+/−,2D6+/− | 10.1 | 3.7 | 13.7 | 2.8 |
4 | fl/fl,CRE+/−,2D6+/− | 10.2 | 2.5 | 12.7 | 4.1 |
MEAN | 10.1 | 2.9 | 13.0 | 3.6 | |
S.D. | 0.3 | 0.5 | 0.6 | 0.6 | |
1 | fl/fl,CRE−/−,2D6−/− | 60.5 | 2.4 | 62.9 | 25.1 |
2 | fl/fl,CRE−/−,2D6−/− | 41.7 | 3.2 | 44.9 | 12.8 |
3 | fl/fl,CRE−/−,2D6−/− | 52.6 | 3.1 | 55.7 | 16.9 |
MEAN | 51.6 | 2.9 | 54.5 | 18.3 | |
S.D. | 9.5 | 0.4 | 9.1 | 6.2 | |
1 | fl/fl,CRE+/−,2D6−/− | 26.2 | 0.9 | 27.1 | 29.2 |
2 | fl/fl,CRE+/−,2D6−/− | 23.0 | 0.8 | 23.7 | 29.8 |
3 | fl/fl,CRE+/−,2D6−/− | 27.2 | 0.8 | 28.0 | 35.3 |
4 | fl/fl,CRE+/−,2D6−/− | 26.7 | 0.8 | 27.5 | 33.8 |
MEAN | 25.8 | 0.8 | 26.6 | 32.0 | |
S.D. | 1.9 | 0.1 | 1.9 | 3.0 |
Animals were dosed with DEB (2.5 mg/kg) and placed in urine metabolic chambers for 24 h. Values from HNF4α-deleted,CYP2D6 humanized mice that are significantly different (p < 0.05) from HNF4α-nondeleted,CYP2D6 humanized mice (see Table 2 for key).