IC50 | n | |
---|---|---|
μM | ||
HERG WT1-a | 0.32 ± 0.04 | 24 |
bEAG T432S/A443S/A453S | 1.1 ± 0.2 | 7 |
bEAG T432S/A443S | <1 | 13 |
bEAG T432S1-a | 7.8 ± 1.2 | 5 |
bEAG WT1-a | 31.8 ± 7.5 | 6 |
bEAG A443S1-a | 41.8 ± 5.0 | 5 |
Concentration-response relationships were fit with Hill equations according to a one-to-one binding scheme (Hill coefficientn = 1). Fits to concentration response curves in bEAG WT assume the same binding scheme. However, better fits could be obtained with Hill coefficients of about 0.6.
↵1-a Ficker et al. (1998).